Valvular and Ventricular Alterations in Bicuspid Aortic Stenosis

Undergraduate researcher
Mathias Dyreborg Jørgensen
Department of Cardiology, Odense University Hospital

Project management

Project status	Open



Data collection dates
Start	01.02.2024
End	01.02.2025

Project in numbers

OPEN survey/clinical data
Expected # of participants	100
Included # of participants	3





Included participants with specimens
Specimens

Valvular and Ventricular Alterations in Bicuspid Aortic Stenosis

Short summary

100 patients with a bicuspid aortic valve will be prospectively included and compared to a matched population of 300 patients with aortic stenosis and a tricuspid valve. Differences in total aortic valve calcium (AVC) and aortic valve calcium density (AVCd) will be assessed by cardiac CT-scan. Differences in left ventricular remodeling and diastolic dysfunction will be assessed by transthoracic echocardiography.

Rationale

Patients with a bicuspid aortic valve have an increased risk of developing aortic stenosis. Aortic stenosis may lead to left ventricular remodeling, diastolic dysfunction and eventually heartfailure, which is more extensive in patients with aortic stenosis and a bicuspid aortic valve. Furthermore patients with a bicuspid aortic valve have larger aortic annuli. This leads to the main hypothesis that for the same degree of AS severity, patients with bicuspid aortic valve have higher AVC due to larger aortic annuli and have more extensive LV remodelling pattern than patients with tricuspid AS. Consequently, AVC density associates better with AS severity than the total calcium load (AVC)

Description of the cohort

Patients with a bicuspid aortic valve confirmed by transthoracic echocardiography will be prospectively included by invitation (eBoks) or during a clinical examination in the cardiology outpatient clinic. Patients will be matched with patients with aortic stenosis and a tricuspid aortic valve identified in our research databases. Patients will be matched based on age, sex and aortic stenosis severity (vmax).

Data and biological material

Data from transthoracic echocardiography and cardiac CT-scans. Questionnaire data assessing comorbidities, symptoms of heart disease, medications etc.