OPEN Research Support
head

Prof., senior consultant
Claus Bistrup
Dept. of Nephrology


Projekt styring
Projekt status    Open
 
Data indsamlingsdatoer
Start 01.12.2023  
Slut 01.02.2025  
 



HINT - Herpes virus infections in kidney transplant recipients

Short summary

Varicella zoster virus (VZV) is a vaccine-preventable disease that causes varicella during primary infection and herpes zoster when reactivated later in life. Kidney transplant recipients have high risk of herpes zoster. Until last year, the only available VZV/herpes zoster vaccines in Europe were live vaccines, and live vaccines are contraindicated in immunosuppressed individuals. We want to the the non-live herpes zoster vaccine in immunosuppressed organ transplant recipeints.


Rationale

1) To determine the antibody vaccine response rate of herpes zoster vaccination (Shingrix®) in kidney transplant recipients that are vaccinated at different time points before and after transplantation and risk factors for non-response. 2) To determine the T cell immunogenicity of herpes zoster vaccination (Shingrix®) in kidney transplant recipients that are vaccinated at different time points before and after transplantation. 3) To determine the antibody persistence after herpes zoster vaccination (Shingrix®) in kidney transplant recipients that are vaccinated at different time points before and after transplantation.


Description of the cohort

Kidney transplant recipients and patients on the waiting list for kidney transplantation


Data and biological material

Blood samples


Collaborating researchers and departments

Dept. of infectious diseases & Dept. of nephrology Copenhagen University Hospital, Dept. of nephrology Aarhus University hospital, Dept. of health technology, Technical University of Denmark