Short summary

Latent autoimmune diabetes in adults (LADA) is the second most common form of diabetes. However, few follow-up studies have been performed. The aim of the present study was to describe clinical aspects in adult patients with LADA during a 12-year period compared to adult patients with type 2 diabetes (T2DM).

Rationale

Latent autoimmune diabetes in adults (LADA) is the second most common form of diabetes. However, few follow-up studies have been performed. The aim of the present study was to describe clinical aspects in adult patients with LADA during a 12-year period compared to adult patients with type 2 diabetes (T2DM). We also want to examine the fraction of individuals presenting with serological conversion from anti-GADab positive to negative state and visa versa. Finally, we want to test whether fasting C-peptide at baseline was a predictor of the need for insulin treatment. Patients with LADA and a matched group patients whom consents to be part of this study will be interviewed and blood will be drawn for biobank purposes.

Description of the cohort

We are inviting randomly selected patients with LADA and duration and gender matched patients with T2DM. All patients have previously been referred to Department of Endocrinology, Odense University Hospital Denmark and have available data on both clinical and biochemical features at baseline.

Data and biological material

Retrospective report

• Demographic data: Age, debut of diabetes, gender, weight and height
• Type of diabetes, metabolism: Fasting C-peptide, anti-GAD titer, fasting plasma glucose, HbA1c, lipid profile, systolic and diastolic blood pressure
• Renal and liver function: Creatinine, ALAT and BASP
• Treatment: Anti diabetic, anti hypertensive, lipid lowering etc.
• Diabetic complications at debut: Retinopathy level, microalbuminuria
• Other autoimmune diseases and TSH, TRAP and TPO antibodies

Follow-up study

• Duration of diabetes and late diabetic complications, medicine
• Blood samples for DNA, auto antibodies (anti-GAD, ICA etc.)
• Blood samples as in retrospective report
• Extra serum and plasma for determination of inflammatory markers (adiponectin, leptin etc.)

Collaborating researchers and departments

Department of Endocrinology, Odense University Hospital

• Research Assistant Mette Wod, MSc
• Professor Kurt Højlund, DMSc
• Professor Henning Beck-Nielsen, DMSc
• Knud Bonnet Yderstræde, MD, PhD