Physician
Amir Emamifar
Department of Medicine, Odense University Hospital, Svendborg
Projekt styring | ||
Projekt status | Closed | |
Data indsamlingsdatoer | ||
Start | 01.05.2017 | |
Slut | 01.08.2019 | |
The current project is focusing on the management of Polymyalgia Rheumatica (PMR) and Giant Cell Arteritis (GCA) with the aim of 18F-FDG Positron Emission Tomography/computed tomography (18F-FDG PET/CT).
Three main areas of concern, including vasculitis process/vascular stiffness, osteoporosis/changes in body composition and malignancy will be evaluated during the project.
The results of our study reveal the role of 18F-FDG PET/CT scan in diagnosis and management of PMR/GCA. Furthermore, our results elucidate the three main problems including: malignancy, osteoporosis/changes in body composition, the vasculitis process, the interaction between them and ultimately elucidate factors for predicting the disease outcome.
Polymyalgia Rheumatica (PMR) and Giant Cell Arteritis (GCA) are common inflammatory conditions. The diagnosis of PMR/GCA possesses many challenges since there are no specific diagnostic tests. Recent literature emphasizes the ability of 18F-FDG PET/CT to assess global disease activity and/or inflammation burden. Vasculitis process/vascular stiffness, malignancy and osteoporosis are important areas of concern regarding the management of PMR/GCA.
Primary objective:
The primary objective of this study is to delineate the association of the 18F-FDG PET/CT detected vasculitis pattern of the large vessels (PET positivity) and the clinical presentation of PMR/GCA.
Secondary objectives:
Study setting:
Department of Rheumatology, Svendborg Hospital, Odense University Hospital Svendborg, Denmark.
Length of study:
One year from the last patient has been enrolled in the study.
Participants:
All new patients with clinical suspicion of PMR/GCA will be offered to be included in the study. At least five (A-E) components of the PMR diagnostic criteria, including: A. Age above or equal to 50 years, B. Bilateral shoulder or hip pain, C. Morning stiffness lasting >45 min, D. Elevated erythrocyte sedimentation rate (ESR), E. Elevated C-reactive protein (CRP), F. Disease duration >2 weeks, should be met to suspect PMR. For GCA the following criterias must be seen: Age >50 years, ESR/CRP >50, as well as at least two symptoms related to vasculitis (scalp tenderness, vision disturbances, headache (new or changed), jaw claudication, tenderness of the temporal arteria) if patients do not simultaneously have PMR. If the patient is suspected for PMR, one cranial symptom is enough to suspect GCA.
Exclusion criteria:
Following data will be collected during the project:
Department of Rheumatology, Odense University Hospital, Svendborg and Faculty of Health Sciences, University of Southern Denmark
Department of Rheumatology, Odense University Hospital, Svendborg.
Faculty of Health Sciences, University of Southern Denmark and Department of Rheumatology, King Christian 10th Hospital for Rheumatic Disease.
Faculty of Health Sciences, University of Southern Denmark and Department of Nuclear Medicine, Odense University Hospital and Department of Radiology and Nuclear Medicine, Southwest Jutland Hospital.
Department of Nuclear Medicine, Odense University Hospital.
Centre of Health Economics Research, University of Southern Denmark.
Department of Endocrinology, Odense University Hospital.
Department of Rheumatology, Odense University Hospital.
Diagnostic Centre, Odense University Hospital, Svendborg.
Diagnostic Centre, Odense University Hospital, Svendborg.
Department of Pathology, Odense University Hospital.
Department of Radiology, Odense University Hospital, Svendborg.
Department of Rheumatology, Southwest Jutland Hospital.