Consultant
Axel Diederichsen
Department of Cardiology, Odense University Hospital
| Projekt styring | ||
| Projekt status | Active | |
| Data indsamlingsdatoer | ||
| Start | 01.05.2009 | |
| Slut | 31.12.2029 | |
The Danish Risk Score Study
Short summary
Arteriosclerosis is a slowly progressing illness process, which happens over many years. The precise mechanism for the formation of arteriosclerosis is not known but a number of risk factors are unambiguously identified. This project will be:
1. A screening study of risk factors for developing a cardiovascular disease with asymptomatic 50-60 year old men and women
2. A randomized study with treatment of magnyl and statin versus placebo for asymptomatic 50-60 year old men and women with coronary calcium
Rationale
The study consists of three sub projects, which all aim to prevent cardiovascular events as well as to optimize effect, security and cost-effectiveness of treatment. In a cohort of randomly selected asymptomatic 50- to 60-year old men and women, it is planned:
Subproject 1:- for subsequent impact calculation for subproject 2
- to identify unknown hypertension, diabetes mellitus or hypercholesterolemia which requires treatment, this is done partly to reveal the extend of the problem and partly to initiate treatment.
- to clarify the variation in coronary calcium linked to the above mentioned risk factores.
- to survey if treatment with Magnyl and Statin-inhibitor is a risk factor for patients with coronary calcium.
- to establish a biobank with biological material for later analyzation in order to find genetic markers for both known risk factors and for the formation of coronary calcium.
Description of the cohort
2000 randomly selected men and women, 50-60 years of age, all from the Region of Southern Denmark are invited to be screened. 50 % of these are expected to accept the offer. The patients will be screened within 2009 and there will be collected one blood sample from each person.
Data and biological material
At the screening session there will be tested for: Calcium score (heart CT), blood pressure, ankle-arm index, height, weight, waist size and lung function test (patients who smoke). Furthermore, blood samples will be collected in order to analyze for: Blood glucose, HgbA1C, cholesterol, lipid profile and CRP.
Collaborating researchers and departments
Department of Cardiology and Cardiovascular, Odense University Hospital
- Acting Senior Hospital Physician Axel Diederichsen, PhD
- 1. registrar Niels C. F. Sandgaard, PhD
- Senior Hospital Physician Hans Mickley, DMSc
- Medical Director Mogens Lytken Larsen, DMSc
Department of Clinical Physiology and Nuclearmedicin, Odense University Hospital
- Senior Hospital Physician Henrik Petersen
- Acting Medical Director and Clinical Associated Professor Allan Johansen
- Senior Hospital Physician and Professor Poul F. Højlund-Carlsen, DMSc
Department of Biostatistics, Institute of Public Health, University of Southern Denmark
- Professor Werne Vach
Department for Research and MTV, Odense University Hospital
- Head of Department and Professor Mickael Bech, PhD, MSc
Clinic of Cardiology and Radiology, Hospital of South Vest Jutland, Esbjerg
- Senior Hospital Physician Majed Husain, MSc
- Senior Hospital Physician Niels Peter Rønnow Sand, PhD
- Senior Hospital Physician Karen Fyhring
Medical Department, The Cardiology Section, Hospital Lillebaelt, Vejle
- Senior Hospital Physician Jesper Møller Jensen, PhD
- Senior Hospital Physician Bjarne Linde Nørgaard, PhD
Medical Department, Odense University Hospital, Svendborg
- Senior Hospital Physician Jess Lambrechtsen, PhD
- Senior Hospital Physician and Professor Kenneth Egstrup, DMSc
Publications associated with the project