Short summary

Objective: The aim is to investigate if the platelet function in HHT patients with epistaxis Method: A case-control study with 30 HHT-patients (epistaxis severity score≥4) and 20 healthy controls match by sex and age is planned.. All will complete a questionnaire regarding bleeding. The platelet function will be assessed by; standard hemostasis parameters, flow cytometry, thromboelastogram, Multiplate (plateletaggregation) and Platelet Function Analyzer 200 (realistic hemodynamic environment).

Rationale

Numerous teleangeictasia increase the risk of bleeding from mucosal surfaces among HHT-patients. The primary hemostasis with the platelet function plays a role in bleeding tendency . The aim is to investigate if the platelet function in HHT patients with epistaxis.

Description of the cohort

30 patients with Hereditary Haemorrhagic Telangiectasia, also known as Morbus Osler. Included via Department of ORL - Head & Neck Surgery.

Data and biological material

Blod samples, questionnaire about bleeding and Epistaxis Severity Score

Collaborating researchers and departments

The Department of Clinical Biochemisty and Pharmacology, Odense University Hospital

• associate professor and Ph.D., Pernille Just Vinholt

Department of ORL - Head & Neck Surgery, Odense University Hospital

• Professor and Ph.D., Anette Drøhse Kjeldsen

Department of Clinical Immunology, Odense University Hospital

• MS and Ph.D., Christian Nielsen