Short summary

Determining the expression of transcriptomes, enzymes, inflammatory proteins and their associated receptors in brain tissue from diseased humans with stroke.

Rationale

By applying spatial transcriptomics and sequencing, cell- and protein specific markers and immunohistochemical techniques the expression of proteins and receptors in brain tissue will be determined from diseased patients with stroke and age-matched diseased without stroke. We hope to provide new knowledge that can contribute to developing new treatments, which can counteract diseases processes in the affected brain tissue.

Description of the cohort

Brain tissue from the Brain Collection is used for these experiments. Tissue from patients with stroke is included in the study as well as control tissue from patients without stroke.

Data and biological material

Brain tissue and patient data from medical records and pathology reports is used in this study.

Collaborating researchers and departments

Department of Molecular Medicine, University of Southern Denmark

• Bettina Hjelm Clausen
• Kate Lykke Lambertsen
• Sarah Boe Tidgen
• Vijay Tiwari