PhD-student
Line Haugaard Fly
Biochemistry and Immunology, Lillebaelt Hospital
| Projekt styring | ||
| Projekt status | Open | |
| Data indsamlingsdatoer | ||
| Start | - | |
| Slut | - | |
SMARTER: Using blood Samples to iMprove FIT-bAsed coloRecTal cancEr scReening
Short summary
In the Region of Southern Denmark, approximately 5,000 colonoscopies are performed each year following a positive colorectal cancer screening. About one-third of these can be considered unnecessary, as no abnormalities are found during the examination. This project aims to reduce the number of these unnecessary procedures by investigating whether blood test results can identify citizens with a very low risk of colorectal cancer, thus potentially sparing them from undergoing a colonoscopy.
Rationale
The colorectal cancer screening program in Denmark, invites citizens aged 50 to 74 to participate every second year. Approximately 25,000 participants are recommended for a colonoscopy each year following a positive stool test indicating blood. However, around 40% of these cases show normal bowel in the colonoscopy. This project aims to determine whether blood tests can predict individuals with no significant findings despite positive stool tests, thus sparing them from undergoing colonoscopy. Given the discomfort, cost, and risks associated with colonoscopy, even a modest reduction in unnecessary procedures could benefit both patients and healthcare budgets. Previous studies suggest that biomarkers in blood tests can indicate a risk for colorectal cancer. A similar study involving general practice patients used routine blood analyses and cancer markers to assess cancer risk. This project builds on those findings, potentially adding biomarkers to improve risk assessment and refine colonoscopy needs.
Description of the cohort
Citizens offered a colonoscopy at Lillebaelt Hospital and Hospital Sønderjylland after a positive test for blood in stool will be offered participation in the study. It is expected that 1000 citizens will be included.
Data and biological material
Blood samples.
Collaborating researchers and departments
Biochemistry, Hospital Sønderjylland