Short summary

Perfluoroalkyl substances (PFAS) are highly persistent chemicals widely used in consumer products making human exposure ubiquitous. Current PFAS levels in the general Danish population are unknown, which makes it difficult to study the impact of future regulations and advise high exposed populations. The aim of this project is to establish PFAS exposure in 1500 Danes aged 18-28 years old.

Rationale

Perfluoroalkyl substances (PFAS) are highly persistent chemicals widely used in consumer products making human exposure ubiquitous. PFAS exposure has been associated with a range of health effects in both children and adults. Current PFAS levels in the general Danish population are unknown. This knowledge gap complicates clinical guidance of vulnerable groups and hinders evaluation of interventions and regulations aimed at reducing PFAS exposure. PFAS cross the placenta and are excreted in breastmilk leading to exposure of the fetus and young child. Exposure of future generations therefore largely depend on PFAS concentrations in young people of reproductive age. Therefore the aim of this project is to measure PFAS serum levels in 1500 Danes aged 18-28 years old.

Description of the cohort

We will be recruiting 1500 18-28 year old Danes from the general population.

Data and biological material

Blood samples Questionnaire data (demografic, dietary habits, health, lifestyle

Collaborating researchers and departments

Department of Occupational and Social Medicine, Holbæk Sygehus

• Chief physician Ann C Lyngberg

Department of Occupational and Environmental Medicine, Bispebjerg Hospital

• Research leader Sandra S Tøttenborg

Department of Occupational and Environmental Medicine, Aalborg Universitetshospital

• Chief physician Jakob Bønløkke