Short summary

The study is the prospective observational study. The purpose is to investigate whether decreasing urinary  Neutrophil Gelatinase-Associated Lipocalin (NGAL) is correlated to recovered renal function after acute kidney injury.

The protein NGAL is the most promising of the new biomarkers for diagnosis of acute kidney injury. Increased creatinine indicate decreased  function of the kidney, while increased NGAL indicate the ongoing damage to the kidney cells.

We know NGAL can be used to diagnose acute kidney injury but can NGAL also be used to assess whether the kidneys after continuous dialysis have regained their function?

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Rationale

The study is the prospective observational study. The purpose is to investigate whether decreasing urinary  Neutrophil Gelatinase-Associated Lipocalin (NGAL) is correlated to recovered renal function after acute kidney injury.

The protein NGAL is the most promising of the new biomarkers for diagnosis of acute kidney injury.

NGAL is a extremely early markers of acute kidney disease. It is rapidly and massively induced in renal failure and possesses kidney-protective activity. Increased creatinine indicate decreased  function of the kidney, while increased NGAL indicate the ongoing damage to the kidney cells.

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Description of the cohort

100 adult intensive care unit patients with acute kidney injury in need of continuous renal replacement therapy.

Data and biological material

Urin NGAL will be measured five times for each patient. The first urine sample is at baseline prior the patients is connected to dialysis; and the other four urine samples is collected  after disconnection of dialysis (respectively at 0,6,12 and 24 hours after disconnection).

Others parameters will be measured as per the departments' norm.

Collaborating researchers and departments

Department of Anesthesiology, Odense University Hospital

• Professor Palle Toft

Department of Clinical Biochemistry and Pharmacology, Odense University Hospital

Department of Clinical Immunology and Biochemistry, Fredericia Hospital

Department of Clinical Immunology and Biochemistry, Kolding Hospital