Short summary

The purpose of the study is to validate an alcohol component in a urine dipstick. The study comprises of three different subprojects, where 12 non-pregnant women initially will consume 1, 2 or 4 units of alcohol, respectively. In the following four days after each subproject, the participants will deliver urine and blood samples. These samples will be tested for alcohol and an alcohol metabolite using mass spectrometry and a newly developed urine dipstick. Data is collected and analyzed using REDCap and OPEN analyse. 

Rationale

Today, alcohol intake can be detected in a blood sample, testing for ethanole. The newly developed urine dipstick detects an alcohol metabolite instead of ethanole itself, prolonging the window of detection. We expect the urine dipstick to be able to detect the alcohol metabolite 3 days after intake of only 2 units of alcohol.

Description of the cohort

12 non-pregnant women

Data and biological material

Blood and urine

Collaborating researchers and departments

Department of Clinical Biochemistry and Pharmacology, Odense University Hospital and Department of Clinical Research, University of Southern Denmark

• Professor, MD, Consultant, Per Damkier

Department of Gynecology and Obstetrics, Odense University Hospital and Department of Clinical Research, University of Southern Denmark

• MD, PhD student, Nete Lundager Klokker Rausgaard

Publications associated with the project

Rausgaard, NLK, Ravn, P, Ibsen, IO, Fruekilde, PBN, Nohr, EA, Damkier, P. Clinical usefulness of a urine dipstick to detect ethyl glucuronide (EtG): A quantitative clinical study in healthy young female volunteers. Basic Clin Pharmacol Toxicol. 2021; 00: 1- 7. https://doi.org/10.1111/bcpt.13558