Short summary

Bariatric surgery (BS) effectively treats obesity and infertility but may impact glucose regulation and fetal growth. We investigate whether pregnant women with BS have a higher risk of hypo- and hyperglycemia and if Roux-en-Y gastric bypass (RYGB) leads to greater glucose variability than sleeve gastrectomy (SG). This multicenter study of 225 women analyzes glucose, activity, blood samples, and fetal growth to improve care for pregnant women after BS.

Rationale

Bariatric surgery (BS) is an efficient treatment of severe obesity and diseases like female infertility. Almost half of the population having BS are women of reproductive age, and BMI above 35 kg/m2 and infertility even serve as eligibility for surgery. BS improves fertility, however with risk of adverse effects on maternal glucose regulation and fetal growth. We hypothesize that pregnant women with BS have a higher frequency of both hypo- and hyperglycemia causing abnormal fetal growth, and that Roux-en-Y gastric bypass (RYGB) results in higher risk of hypoglycemia and larger glucose variability than sleeve gastrectomy (SG).

Description of the cohort

In this prospective, multicenter study, we will include 225 pregnant BMI, age, and parity-matched women from four obstetric departments: 75 with RYGB, 75 with SG and 75 without BS.

Data and biological material

Data include continuous glucose monitoring, activity tracking, blood sampling, questionnaires, and fetal growth.

Collaborating researchers and departments

Departments of Gynecology and Obstetrics at Esbjerg and Grindsted Hospital

Departments of Gynecology and Obstetrics atLillebaelt Hospital