Masters student
Gregers Gaardskær Boel
Department of Surgery at Odense University Hospital
| Project management | ||
| Project status | Open | |
| Data collection dates | ||
| Start | 25.08.2024 | |
| End | 01.01.2026 | |
Postopereative complications following surgery in congenital hyperinsulinism and insulinomas
Short summary
This study is a Retrospective cohort study, aiming to chart the most frequent and dangerous complications following pediatric pancreas surgery. 100 patients treated at the international hyperinsulinism center at Odense university hosptial will be included.
Rationale
Despite being a rare condition affecting between 1 in 40.000 to 50.000 births, CHI is the most common cause of persistent hypoglycemia in children, with a high risk of neurological dysfunction and sequelae if left untreated. Cases of CHI, which do not respond sufficiently to first line treatment, may require surgical intervention in the first months of life to obtain either normoglycemia or sufficient response to pharmacological intervention. Patients may require either the removal of a focal insulin producing lesion in the pancreas, or near total pancreatectomy (90-95 %) in the case of diffuse/atypical CHI. CHI patients undergoing surgery have a risk of developing diabetes during long term follow-up, however, there is a lack of studies describing short term postoperative outcome and complications. Like CHI, insulinomas can be a cause of continuous elevated levels of serum insulin while fasting and therefore require resection to stabilize insulin and blood glucose levels. The incidence of insulinomas in the adult population is estimated to be 4 cases per million/year, with only 6% of cases occurring in children under 20 years. Data on pediatric insulinomas is generally lacking with few case reports and cohorts recorded.
Description of the cohort
Patients reffered to the international hyperinsulinism center, having undergone surgery for congenital hyperinsulinism or insulinomas. at Odense Pancreas center, hepato-pancreat-biliary section and center for pediatric surgery.
Data and biological material
Patiant journal data from the National patient registry.