Short summary

Clonidine has dual action. Being an analgesic and anxiolytic drug. It's given once after major abdominal surgery to patients diagnosed with cancer. Use of morphine the next 24 hours is the primary endpoint. Certain pharmacodynamic, pharmacokinetic and pharmacogenetic aspects are measured thereby characterize efficacy in different subgroups. Chronic pain after 6 mo. are measured. We address the effect of certain genes on pain perception & the analgesic effect of clonidine & morphine.

Description of the cohort

Patients diagnosed with cancer sheduled for abdominal surgery

Data and biological material

Blod, maybe urine, demografic, diagnosis, quistionnaires, data from the patient journal, QST-measurements, monitoring data, verbal respons, use of medication

Collaborating researchers and departments

Klinisk Genom Center, Odense University Hospital and the University of Southern Denmark

Dept. of Pharmacology. University Hospital of Cologne (Køln), Germany