MD, PhD
Mathias Rathe
Department of Pediatrics Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark
| Project management | ||
| Project status | Open | |
| Data collection dates | ||
| Start | 01.08.2024 | |
| End | 01.08.2027 | |
ADRENAL FUNCTION FOLLOWING INDUCTION TREATMENT FOR ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN: A COMPARISON OF PREDNISOLONE AND DEXAMETHASONE
Short summary
In this single-center retrospective comparative cohort study, we reviewed adrenal fundtion in 62 pediatric patients treated either according to the Nordic Society of Pediatric Hematology and Oncology (NOPHO) ALL2008 protocol or the ALLTogether1 protocol.
Rationale
Children and adolescents with acute lymphoblastic leukemia (ALL) receive high-dose glucocorti-coid therapy as a part of their treatment. Abrupt cessation or rapid withdrawal of glucocorticoids may result in adrenal suppression. The aim of this study was 1) to assess differences in adrenal suppression following induction treatment with prednisolone or dexamethasone, and 2) to examine the influence of potential risk factors including gender, age, and immunophenotype.
Description of the cohort
A single-center retrospective comparative cohort study of pediatric patients treated for ALL at the H. C. Andersen Children's Hospital, OUH between January 1st, 2009, and December 31st, 2023. Eligible patients were < 18 years old at the time of diagnosis