Short summary

Orthokeratology lenses (OKL) have proven to be effective in reducing myopia progression by slowing axial length elongation, but the efficacy varies among children. The key objective of the study is to gain an understanding of the biochemical processes that contribute to OKL being more effective in specific individuals compared to others. With this knowledge, we hope to optimize treatment effectiveness in those currently experiencing less favorable outcomes from treatment in the future.

Rationale

In recent decades, myopia has become a global health concern. The prevalence of myopia is predicted to be 50% of the world's population in 2050. Individuals with myopia are at an increased risk of sight-threatening complications such as retinal detachment, myopic degeneration, glaucoma, and cataract. The primary aim is to investigate differences in protein levels in children using orthokeratology lenses with various effects of myopia control.

Description of the cohort

Children who are currently being treated with orthokeratology lenses at the Ophthalmic Department, Vejle Hospital, University Hospital of Southern Denmark.

Data and biological material

Age, axial length six months before data collection, cSER before OKL initiation, treatment duration at the time of contact lens collection, axial length progression past six months.

Collaborating researchers and departments

Department of Ophthalmology, Vejle Hospital

• MD, PhD, Associate Professor of Ophthalmology Flemming Møller
• MD, PhD, Postdoc Trine Møldrup Jakobsen
• MD, PhD-student Lou-Ann C. Andersen

Department of Ophthalmology, Aalborg University

• MD, PhD, Associate Professor of Ophthalmology Lasse Cehofski