Short summary

Blood stream infection with anaerobic bacteria is associated with significant mobidity and mortality. In two population-based cohort studies based on register data, we will examine the risk factors for and the mortality of anaerobic bacteraemia. Furthermore we will examine outcome in relation to antibiotic treatment.

Rationale

What is the level of underlying diseases, including cancer, in Danish patients following hospitalization with anaerobic bacteremia? What are the fatality rates in Danish patients with clinically significant anaerobic blood stream infection? In addition, what risk factors are associated with mortality? Given the marked progress in microbiological diagnostics and the changes in antimicrobial susceptibilities, and empirical antibiotic therapy, do patients with Bacteroides bacteremia receive appropriate therapy and how does this contribute to patient survival?

Description of the cohort

Adults hospitalised with anaerobic bacteremia in Denmark between 2010 and 2023.

Data and biological material

Data from the national registries (National Patient Registry, Cause of Death Registry, Danish Microbiology Database (MiBa), Danish Colorectal Cancer Database (DCCG) ).

Collaborating researchers and departments

Department of Surgery, Odense University Hospital and Svendborg Sygehus.

• Professor Mark Bremholm Ellebæk
• Associate Professor Thomas Bjørsum-Meyer

Center for Clinical Epidemiology, Odense University Hospital (OUH).

• Associate Professor Kim Oren Gradel

Publications associated with the project

Justesen US, Nielsen SL, Jensen TG, Dessau RB, Møller JK, Coia JE, et al. Bacteremia with anaerobic bacteria and association with colorectal cancer: a population-based cohort study. Clin Infect Dis 2022;75:1747-53.

Justesen US, Ellebæk MB, Quist N et al. Colorectal cancer and association with anaerobic bacteraemia: A Danish nationwide population-based cohort study. Journal of Infection 89 (2024) 106212