Short summary

In 3 out of 4 women with a positive screening for breast cancer, subsequent tests show that they do not have cancer. We will investigate whether a blood test can be used to find women without breast cancer. This will allow these women to be spared from tests that many find unpleasant and psychologically stressful. This will also free up time and resources in the health care system.

Rationale

Breast cancer screening is offered to all Danish women aged 50-69. Around 2.5% are recalled after suspicious findings, but only one in four actually have cancer. The rest experience discomfort, anxiety and unnecessary tests. In Norway, fewer interval cancers are seen at a higher recall rate, but this increases the pressure on the healthcare system. A blood-based test can be a gentle and resource-saving supplement that targets efforts to those in greatest need. Project question Can blood-based biomarkers identify women at low risk of breast cancer among those recalled after screening, thereby reducing the need for unnecessary tests - without compromising the ability to find cancer cases early? This will free up more resources for high-risk patients.

Description of the cohort

Women who are recalled to supplementary examination at Vejle or Odense Hospital after initial mammography screening

Data and biological material

blood, samples, data from patients medical journals, possibly mammography images

Collaborating researchers and departments

Røntgen og Scanning, Lillebaelt hospital

• Mammografiafsnittet

Blodprøver og biokemi, Odense Universitetshospital

Radiologisk afdeling, Odense universitetshospital

• Mammografi, mammografiscreening