OPEN Research Support

Joshua Buron Feinberg
Department of medicine, cardiology section, Holbæk Hospital

Projekt styring
Projekt status    Open
Data indsamlingsdatoer
Start 01.03.2021  
Slut 01.09.2026  

Lenient rate control versus strict rate control for atrial fibrillation. The Danish Atrial Fibrillation (DanAF) randomised clinical trial

Short summary

Randomised trial, comparing a lenient rate control strategy with a strict rate control stategy in patients with permanent atrial fibrillation.

350 participants will be recruited from Holbæk, Hvidovre, Odense and SUH-Roskilde.

Primary outcome is SF-36 physical component score. Primary assessment time point is after 1 year.


Atrial fibrillation is the most common heart arrhythmia with a prevalence of approximately 2% in the western world and with rising prevalence in the world and in Denmark. Atrial fibrillation is associated with an increased risk of death and morbidity and debilitating symptoms such as palpations and shortness of breath.

For many patients, a rate control strategy is recommended over a rhythm control strategy. The optimal heart rate target is controversial despite the results of the RACE II trial.

Description of the cohort

Participants with permanent atrial fibrillation recruited from Holbæk, SUH-Roskilde, Odense and Hvidovre Hospital

Data and biological material

blood samples, questionnaire data, data from patient journals, diagnosis, accelerometer data, echocardiography.

Collaborating researchers and departments

Department of cardiology, Odense University hospital

  • Axel Brandes

Department of cardiology, Hvidovre University Hospital

  • Ulrik Dixen
  • Ilan Raymond

Department of cardiology, Zealand University Hospital - Roskilde

  • Ole Dyg Pedersen
  • Uffe Gang