Autologous Fat Grafting as Treatment of Postherpetic Neuralgia A randomized clinical trial
Post-Herpetic Neuralgia (PHN) is a chronic pain syndrome that occurs after an outbreak of herpes zoster/shingles. Approximately 5-30% of patients experiencing an outbreak of shingles will have chronic pain >90 days after the resolution of the rash. No effective treatment or cure excists. Our pilot trial have shown promising results in treating and possibly curing PHN using autologous fat grafting. We therefore aim to further test the procedure in this randomized clinical trial.
Herpes Zoster (HZ), is a condition caused by Varicella-Zoster virus (VZV), The disease is caused by reactivation of a latent VZV-infection in the sensory ganglia.
Clinically the condition is characterized by a painful, unilateral, vesicular rash. Pain is the most prominent symptom in around 90% of patients. In 10% of patients, this pain remains and becomes chronic.
Post-herpetic neuralgia (PHN) is a chronic pain syndrome that occurs after the dermal manifestation disappears. Treatment is complex and mainly topical or systemic. For many patients, this is not sufficient and they live with constant pain.
Autologous fat grafting has shown promise in treating several different painful conditions such as post-mastectomy pain syndrome, painful scars, etc. Our previous pilot study (NCT03584061) investigating the effect of autologous fat grafting on PHN, showed a marked reduction in pain with half of the patients being pain-free after the procedure.
The aim of this study is to test the hypothesis that autologous fat grafting is more effective than a sham operation in treating PHN.
Description of the cohort
Adult patients suffering form PHN are recruited from the relevant departments at Odense University Hospital. Information about the project can also be found on the hospitals website (ouh.dk) and on clinicaltrial.org.
- Age over 18
- Pain in area of former VZV-infection.
- Pain present over 3 months after reactivation of VZV and is present at least 4 days a week and of intensity >3 on the VAS-scale
Psychiatric illness that could potentially affect the study.
Collaborating researchers and departments
Research Unit for Plastic Surgery, Odense University Hospital
- Professor Jens Ahm Sørensen
Department of Plastic Surgery, Odense University Hospital
- Consultant Jørn Bo Thomsen