OPEN Research Support
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Pharmaconomist
Trine Simonsen
Sygehusapotek Fyn, Odense Universitetshospital


Projekt styring
Projekt status    Sampling ongoing
 
Data indsamlingsdatoer
Start 01.02.2020  
Slut 01.03.2022  
 



Attitudes towards deprescribing among geriatric patients using psychiatric medication

Short summary

While older people often take a lot of medication, they are also more susceptible to the potential adverse effects of drugs compared with younger people. Futher, for older people taking psychiatric medication, they are at high risk of experiencing side effects, while the effect of treatment with many combinations of psychiatric drugs is also unknown. Deprescribing, defined as the planned, supervised dose reduction or stopping of a medication, can be used to optimize medication use. However, in order to effectively carry out deprescribing, it is important to understand how the patients feel about it. Thus, we aim to explore attitudes towards deprescribing among geriatric patients using psychiatric medication.


Rationale

Deprescribing is defined as the planned, supervised dose reduction or stopping of a medication, and can be used to optimize medication use. Before initiating any deprescribing, however, it is important to gain insight into patients' perspectives on it. In 2016, an Australian research team developed the revised Patients' Attitudes Towards Deprescribing (rPATD) questionnaire which is a 22-item self-report instrument capturing older patients' beliefs and attitudes towards deprescribing. The questionnaire has been used in several studies which have all found that older people generally want to reduce their use of medication. A Danish research team has recently translated, cross-culturally adapted, and validated the questionnaire into Danish in a cohort of nursing home residents. However, attitudes towards deprescribing among geriatric patients using psychiatric medication remain to be investigated. 


Description of the cohort

The project will include geriatric patients using psychiatric medication. Patients will be recuited from psychiatric ambulatories in the Region of Southern Denmark. Only patients with an OMC-score of 8 or higher and in a stable treatment will be included. 


Data and biological material

Attitudes towards deprescribing among geriatric patients using psychiatric medication. Attitudes will be explored using the rPATD questionnaire. 


Collaborating researchers and departments

Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, and Hospital Pharmacy Funen, Odense University Hospital

  • PhD student Carina Lundby

Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, and Hospital Pharmacy Funen, Odense University Hospital

  • Head of Research, Professor Anton Pottegård

Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, and the Psychiatry in the Region of Southern Denmark

  • Clinical pharmacologist Maija Bruun Haastrup

Clinical Biomechanics, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark

  • Associate Professor Henrik Hein Lauridsen

Psychiatric departments in the Region of Southern Denmark: 
Odense (contact person: Professor, Consultant Kjeld Andersen),
Vejle (contact person: Consultant Connie Thurøe Nielsen),
Aabenraa (contact person: Consultant Lene Høgh)
Esbjerg (contact person: Consultant Krzystof Mateusz Siwiec). 

Publications associated with the project

Lundby C, Graabæk T, Ryg J, Søndergaard J, Pottegård A, Nielsen DS. Health care professionals' attitudes towards deprescribing in older patients with limited life expectancy: A systematic review. Br J Clin Pharmacol. 2019;85(5):868–92. 

Lundby C, Graabæk T, Ryg J, Søndergaard J, Pottegård A, Nielsen DS. ‘… Above All, It's a Matter of? This Person's Quality of Life': Health Care Professionals' Perspectives on Deprescribing in Older Patients With Limited Life Expectancy. The Gerontologist. 2019. 

Thompson W, Lundby C, Graabaek T, Nielsen DS, Ryg J, Søndergaard J, et al. Tools for Deprescribing in Frail Older Persons and Those with Limited Life Expectancy: A Systematic Review. J Am Geriatr Soc. 2019;67(1):172–80. 

Thompson W, Jacobsen IT, Jarbøl DE, Haastrup P, Nielsen JB, Lundby C. Nursing Home Residents' Thoughts on Discussing Deprescribing of Preventive Medications. Drugs Aging. 2020; [Epub ahead of print].