Clinical Nurse Specialist Hrønn Thorn Department of Oncology, Vejle Hospital
Projektet i tal
OPEN undersøgelse/kliniske data
Forventet # af deltagere
Inkluderet antal deltagere
Inkluderede deltagere med prøver
Can White Tea Prevent Oral Mucositis in Patients, Receiving Neoadjuvant or Adjuvant Therapy with Paclitaxel for Breast Cancer? A Randomized Controlled Trial
The aim of this study is to determine the effectiveness of mouthwash with white tea in the prevention of paclitaxel induced oral mucositis in women with breast cancer.\n
Oral mucositis is a common side effect from paclitaxel therapy. Oral mucositis can be very painful and comprise nutrition and oral hygiene and may increase the risk for infection. Although oral mucositis is a common side effect to chemotherapy no available treatment is yet found that can effectively prevent or treat oral mucositis.
Based on the knowledge that white tea have anti-inflammatory, anti-oxidant and anti-microbial effect, the current study aims to assess the effect of mouth wash with white tea on paclitaxel induced oral mucositis in women with breast cancer.
This study is a phase II randomized controlled trial in which eligible patients will be allocated to a control group (CG) or to a study group (SG). The CG will use salt water with soda for mouthwash eight to ten times a day and the SG will use white tea for mouthwash five to six times a day.
Description of the cohort
Adult women with breastcancer treated with paclitaxel\n
Data and biological material
Primary outcome: Incidence of oral mucositis of grade 2 or higher measured on Revised Oral Assessment Guide (ROAG) once a week over a period of nine weeks
Secondary outcomes: Frequency of daily mouthwash
Frequency of daily tooth brushing
Pain intensity in the oral cavity measured on
Day of onset of oral mucositis of grade 2 or higher measured on ROAG