Chief Physician, Professor Kurt Højlund Steno Diabetes Center Odense, Odense University Hospital
Projektet i tal
OPEN undersøgelse/kliniske data
Forventet # af deltagere
Inkluderet antal deltagere
Forventede deltagere med prøver
Inkluderede deltagere med prøver
Adipose tissue dysfunction in type 2 diabetes and its reversibility by bariatric surgery (ADIDYS)
We intent to test the hypotheses 1) that T2D is associated with exaggerated AT dysfunction compared with obesity alone, 2) that increased insulin sensitivity and remission of T2D after bariatric surgery is in part explained by improved AT function. This will be done to recruit 30 participants who will undergo bariatric surgery, which of 15 will have T2D and 15 without, and test them extensively prior to surgery and agian 9-12 month after surgery.
Insulin resistance (IR) plays a major role in the pathogenesis of type 2 diabetes (T2D). Adipose tissue (AT) dysfunction leading to systemic low-grade inflammation and ectopic lipid deposition plays an important role in obesity-induced IR, but its role in T2D pathogenesis and to what extent insulin-sensitizing interventions can reverse AT dysfunction remain to be clarified.
Description of the cohort
30 patients eligible for bariatric surgery: 15 obese with type 2 diabetes, 15 obese without type 2 diabetes. Will be testet two times: before operation and one year after.
15 lean healthy controls whioch will be testet one time.
Data and biological material
Blood samples, urine, DEXA scan,anthropometric measurements, indirect calirometry, VO2max, muscle and fat biopsies, insulin sensitivity test and beta cell function test.
Collaborating researchers and departments
Department of Biochemistry and Molecular Biology, University of Southern Denmark
Professor Nils Færgeman
Department of Clinical Genetics, Odense University Hospital
Associate Professor, PhD Klaus Brusgaard
Department of Endocrinology, Hospital of Southwest Jutland