Assesment of tensile strenght and histological features of cerebral aneurysms.

MD, PhD
Troels Halfeld Nielsen
Department of Neurosurgery

Project management

Project status	Open



Data collection dates
Start	01.01.2017
End	01.01.2025

Project in numbers

OPEN survey/clinical data
Expected # of participants	100
Included # of participants	68



OPEN Biobank
Expected participants with specimens	100
Included participants with specimens
Specimens

Assesment of tensile strenght and histological features of cerebral aneurysms.

Short summary

It is still unknown why some cerebral aneurysms rupture, while the majority don't. The present project aims at assessing histological features and wall tensile strengh in both ruptured and unruptured aneurysms. We will explore the differences between the two kinds of aneurysms.

Description of the cohort

Patients are prospectively included the the departments of Neurosurgery at Rigshospitalet and Odense University Hospital

Data and biological material

Aneurysm wall from both ruptured and unruptured cerebral aneurysms are harvested during microsurgical clipping. The tissue are examined in respect to wall tensile strengh, histological features and proteomics.

Collaborating researchers and departments

Department of Neurosurgery, Rigshospitalet