Short summary

With this project we establish a clinical database of women with pathogen variant in high-risk or moderate-high-risk gene for lower body cancer from a genetic tree analysis; i.e. hereditary ovarian cancer (HOC). We measure the endocrinological and cardiovascular profile, and quality of life and sexuality by validated questionnaires before and after risk reducing bilateral saplingo-oopherectomy (RRBSO) at time points 1, 5, 10, 15 and 20 years after surgery.

Rationale

Long-term, prospective data of this group of women are few. Guidelines recommend risk reducing salpigo-oopgorectomy (RRBSO) at the age of 35-40 years for relevant oncogenic mutations i.e. up to 15 years before natural menopause. Women without previous breast cancer are recommended postoperative hormone replacement therapy until 51 years of age i.e. for up to 15 years. Presently, prospective data of up to only five years after surgery exist. These data shows that about 50 % stop hormone therapy after few years. Long-term data and better clinical follow-up are thus needed.

Description of the cohort

Women with pathogen variant in high-risk or moderate-high-risk gene for lower body cancer from a genetic tree analysis; i.e. hereditary ovarian cancer (HOC); before and after risk reducing salpigo-oopgorectomy (RRBSO).

Data and biological material

Endocrinological and cardiovascular profile, and quality of life and sexuality by validated questionnaires before and after risk reducing bilateral saplingo-oopherectomy (RRBSO) at time points 1, 5, 10, 15 and 20 years after surgery.

Collaborating researchers and departments

Department of Gynecology & Obststrics, Herlev Hospital

• Kresten Rubeck Petersen
• Klara Naver