Systemic lupus erythematosus in Southern Denmark
Systemic lupus erythematosus (SLE) is a prototypic, autoimmune and potentially fatal connective tissue disease. In spite of its rarity (yearly incidence in Denmark 1-2/100.000) SLE has been intensively studied throughout the world clarifying a pathogenesis of multiple, complement activating autoantibodies causing inflammation and consequently tissue and organ damage.
We investigate the epidemiology of SLE prospectively since 1995 expanding the cohort to 208 patients as of 2013, with 1-6 consecutive blood samples from each patient coupled with a database covering disease manifestations, disease activity-scores, medical treatment etc.
Cardiovascular diseases (CVD) is an important negative predictive factor of survival in SLE and we presently investigate risk-factors including signs of atherosclerosis including coronary artery calcification measured by heart CT scans and carotid intima media thickening/plaques measured by means of B-mode ultrasound scans.
The aim is to identify and maintain a population-based cohort of SLE patients covering the Region of Southern Denmark. A database and a biobank are cultivated in order to describe potential biochemical markers of activity and damage in SLE
Description of the cohort
A population-based cohort of well characterized patients with SLE recruited from the Rheumatologic Departments in the Region of Southern Denmark.
We consecutively include incident and immigrated SLE patients aged 18+. Patients are invited to specific research-visits every 5 year including review of medical history, a clinical examination and blood-sampling. Extra examination and blood-sampling is performed if disease activity is suspected in-between research-visits.
Data and biological material
Clinical data concerning diagnosis, activity score, damage score and risk factors for cardiovascular diseases.
Heart CT scans and carotid intima media thickening/plaques measured by means of B-mode ultrasound scans.
Serum (1-6 consecutive samples), plasma (1-4 consecutive samples) and DNA.
Collaborating researchers and departments
Department of Rheumatology, Odense University Hospital
- Associate professor Anne Voss, MD, PhD
- Helle Laustrup, MD, PhD,
- PhD student Susan Due Kay, MD
Publications associated with the project
Systemisk lupus erythematosus i Fyns Amt. En epidemiologisk undersøgelse. / Voss AB, Green A, Junker P. Ugeskr Laeger 1999;161:3837-40
Occurrence of systemic lupus erythematosus in a Danish Community: an 8-year prospective study. / Laustrup H, Voss A, Green A, Junker P. Scand J Rheumatol 2009;38:128-32
SLE disease patterns in a Danish population-based cohort: an 8-year prospective study. / Laustrup H, Voss A, Green A, Junker P. Lupus 2010;19:239-46
Survival in systemic lupus erythematosus, 1995-2010. A prospective study in a Danish community. / Voss A, Laustrup H, Hjelmborg J, Junker P. Lupus. 2013;22:1185-91