MD Ulla Lei Larsen Department of Anaesthesiology & Intensive Care, Odense University Hospital, Odense, Denmark; University of Southern Denmark, Odense, Denmark.
Projektet i tal
OPEN undersøgelse/kliniske data
Forventet # af deltagere
Inkluderet antal deltagere
Inkluderede deltagere med prøver
Enteral feed of critical ill infants with congenital diaphragmatic hernia in the pre- and postoperative period.
Infants with congenital diaphragmatic hernia develop a defect of the diaphragm during pregnancy. The displaced abdominal organs compromise heart and lung function at birth and the infants need intensive care treatment and surgical repair. These infants are at risk of impaired growth. Our unit has practiced enteral feeding in the preoperative period for the past 25 years, which is in disagreement with the recent published European guidelines. We believe early enteral feeding provide the benefits
Part 1: Retrospective cohort study
1) Describe the current approach to feeding CDH-infants in the pre- and postoperative period at OUH.
2) Assess clinical outcomes: Primary outcomes; time to full enteral feeding and growth, Secondary outcomes; mortality, length of stay, time on mechanical ventilation, use of antibiotics and complications in terms of gastrointestinal issues and need for other surgical procedures.
Part 2: Register-based study
3) Describe growth and new admissions to hospital (focus on referrals for abdominal/growth issues and infections) up to age 5 yr.
Part 1: Will add valuable information on the initial treatment of CDH-infants, with the potential to enhance the benefits of breast milk and reduce the need for parenteral nutrition.
Part 2: Will add new information on growth and complications in early childhood. These issues have the potential to affect quality of life and the study will be the first to describe the Danish population of CDH-infants. The results will contribute to a better counseling of families expecting a CDH-child. These families are often faced with the decision of continuing the pregnancy or applying for a termination.
Description of the cohort
Infants with congenital diaphragmatic hernia presenting with symptoms within the first 24 hours of life. All infants was treated at Odense University hospital, pediatric intensive care unit.
Data and biological material
Data is collected retrospectively (prospectively registered) fra medical journal and electronic critical information system (CIS)
Collaborating researchers and departments
Department of abdominal surgery, University Hospital, Odense, Denmark: University of Southern Denmark.
Prof Niels Qvist
Department of neonatology, HC Andersen Pediatric Hospital,University Hospital, Odense, Denmark: University of Southern Denmark.