M.D PhD.
Issam al-Najami
Department of surgery
| Project management | ||
| Project status | Open | |
| Data collection dates | ||
| Start | 01.02.2021 | |
| End | 01.02.2023 | |
The chemopreventive effect of carrots on bowel inflammation
Short summary
Studies have shown an effect of carrots and the polyacetylenes falcarinol and falcaridiol on the formation of the precancerous colorectal polyps in rat models, furthermore it is suggested that falcarinol and falcaridiol have a variety of bio-effects including anti-inflammatory, antiplatelet-aggregatory, cytotoxic, antitumor activity.Our objective is to assess the effect of a dietary intake of falcarinol and falcaridiol in carrots on altering the iFOBT test from positive to negative.
Rationale
Studies have shown an effect of carrots and the polyacetylenes falcarinol and falcaridiol on the formation of the precancerous colorectal polyps in rat models, furthermore it is suggested that falcarinol and falcaridiol have a variety of bio-effects including anti-inflammatory, antiplatelet-aggregatory, cytotoxic, antitumor activity. The anti-proliferative effect of falcarinol and falcarindiol on cancer cells is probably related to their ability to arrest the cell cycle progression at G2/M or other phases of the cell cycle. The anti-proliferative effect of falcarinol and falcarindiol could be due to induction of apoptosis at both earlier and later stages of the cell cycle.
Description of the cohort
Patients are enrolled from the national screening program for colorectal cancer. Patients are eligible if they have a so-called false positive FIT, meaning a positive FIT stool test but a negative colonoscopy with no findings.
Data and biological material
Blood and stool samples will be analysed before and after intake of carrots.
Collaborating researchers and departments
Department of Biochemistry OUH, Svendborg