OPEN Research Support

Biochemist, Associate Professor
Martin Overgaard
Department of Clinical Biochemistry and Pharmacology

Projekt styring
Projekt status    Open
Data indsamlingsdatoer
Start 02.09.2019  
Slut 01.09.2020  

SugarMum: Screening for gestational diabetes mellitus and abnormal fetal growth

Short summary

This study investigates how implementation of the new WHO-recommended diagnostic criteria as well as universal screening for gestational diabetes mellitus (GDM) will affect the prevalence of GDM in Denmark. Furthermore, we will explore the potential of multivariate models based on maternal risk factors combined with biomarkers in first and second trimester as alternative screening methods for GDM and large for gestational age (LGA) infants.


Background: In 2013, WHO presented new international recommendations for screening and diagnosis of gestational diabetes mellitus (GDM). Studies indicate that these guidelines are not suitable for all populations, and one study has implied that the prevalence of GDM in Denmark would rise from 4.7 % to more than 40 %, if implementing the WHO threshold for fasting plasma glucose (FPG) alone. Objective: To clarify the consequences of implementing WHO recommendations for GDM testing in Denmark by comparing the new WHO method with the current Danish in a prospective study.

Description of the cohort

Prospective cohort of pregnant women attending first trimester screening at Hospital of North Zealand, Hillerød.

Data and biological material

Biobank (serum and plasma) from gestation weeks 11-14 and 24-28. Data from medical records (maternal characteristics, medication and pregnancy outcome)

Collaborating researchers and departments

Department of Gynecology and Obstetrics, Nordsjællands Hospital, Hillerød

  • Cathrine Scheuer, PhD student, Tine Dalsgaard Clausen, Consultant, and Associate professor, PhD

Center for Pregnant Women with Diabetes, Rigshospitalet.

  • Professor Peter Damm
  • Professor Elisabeth Mathiesen

Steno Diabetes Center Odense/The Research Unit for Gynecology and Obstetrics, OUH.

  • Professor, Dorte Møller Jensen

Faculty of Medicine, Mater Clinical Unit, The University of Queensland, Australia.

  • David McIntyre