MD, PhD Student Anna Sofie Koefoed Gynaecology and Obstetrics, Aarhus University Hospital
Projektet i tal
OPEN undersøgelse/kliniske data
Forventet # af deltagere
Inkluderet antal deltagere
Forventede deltagere med prøver
Inkluderede deltagere med prøver
Hormonal and inflammatory changes during pregnancy in women with glucose metabolic disorders (HI-MET)
This is a prospective observational study including app. 300 pregnant women with and without diabetes and overweight.
Hormonal profiles and inflammatory markers will be measured in the blood at gestational week 8-10, 10-14, 18-22, 24-28 and 34-38. Height, weight, and blood pressure will be measured as well and a urine sample will be collected. Insulin sensitivity will be estimated using the homeostasis model assessment, IS-HOMA, based on fasting insulin and glucose concentrations.
During all pregnancies the maternal insulin sensitivity decrease, which can have severe consequences for women with diabetes and their children short- and longterm. The mechanisms behind this change is unknown, however studies have linked it to different hormonal, inflammatory and metabolic factors in women with gestational diabetes or type 1 diabetes. Studies on women with type 2 diabetes remain to be performed.
The first aim of this study is to describe maternal hormonal and inflammatory changes during pregnancy in women that differ metabolically (limited to women with type 2 diabetes, gestational diabetes and/or overweight).
The second aim of this study is to examine maternal hormonal, inflammatory and metabolic factors associated with insulin sensitivity in human pregnancy.
Description of the cohort
The study includes app. 300 pregnant women from the outpatient clinics at Department of Obstetrics and Gynecology at Aalborg, Odense and Aarhus University Hospital. 50 healthy normal-weight women, 150 healthy overweight women, 50 women with gestational diabetes and 50 women with type 2 diabetes.
Data and biological material
Biological material (blood and urine samples).
Objective measurements (height, weight and blood pressure).
Data from the patient journal.
Collaborating researchers and departments
Gynaecology and Obstetrics, Aarhus University Hospital
Per Glud Ovesen, MD, Dr. Med., Professor
Magnus Møller, MD, PhD Student
Steno Diabetes Center Aarhus, Aarhus University Hospital
Ulla Kampmann Opstrup, MD, PhD, Associate Professor
Sine Knorr Johnsen, MD, PhD, Post Doc
Steno Diabetes Center Odense, Odense University Hospital
Dorte Møller Jensen, MD, PhD
Gynaecology and Obstetrics, Odense University Hospital
Lise Lotte Torvin Andersen, MD
Gynaecology and Obstetrics, Aalborg University Hospital
Anne Nødgaard Weidemann Sørensen, MD, PhD, Associate Professor