Physician Shakespeare Jeromdesella KMEB, department of Endocrinology, OUH
Projektet i tal
OPEN undersøgelse/kliniske data
Forventet # af deltagere
Inkluderet antal deltagere
Inkluderede deltagere med prøver
Studies on effects of age and diseases on cellular heterogeneity of human bone-marrow stromal stem cells
The aim of this project is to determine Bone marrow stromal (skeletal) stem cells (BM-MSCs) subpopulations molecular properties, biological features, osteogenic differentiation capacity along with their spatial anatomical localization in vivo. This study investigates the gender-related, age-related and osteoporosis related changes in BM-MSC heterogeneity.
Osteoporosis is one of the most serious threats to public health in the industrialized world. The risk of a person getting an osteoporotic fracture during his life is 40-50% for women and 13-22% for men. These fractures are associated with serious health complications and economic consequences for society. Bone marrow stromal cells are multipotent stem cells with a finite replicative capacity. During their proliferative state, they can differentiate into mainly osteoblasts, chondrocytes and adipocytes. During the aging process, their ability to proliferate and differentiate becomes impaired, affecting their function and contributing to age-related pathologies such as osteoporosis. Blood biomarkers can be associated with the bone aging process and can also help assess the risk of bone fractures in patients with osteoporosis, but to understand what drives the aging process at the cellular level in the first place, it is imperative to characterize the cellular heterogeneity found among the cells. This knowledge would help to distinguish the molecular signatures among different individuals with different ages and metabolic state and provide information to reduce the cellular heterogeneity of the cells used for therapy with the aim of enhancing their therapeutic potential.
Description of the cohort
10 healthy males and females 20-35 years old
10 healthy males and females 65-80 years old
40 patients with Osteoporosis
Data and biological material
bloodsamples, bonemarrow aspirate and bone biopsi.