Medical student Anne Lørup Lyster Department of Medical Gastrointestinal Diseases, Odense University Hospital
Projektet i tal
OPEN undersøgelse/kliniske data
Forventet # af deltagere
Inkluderet antal deltagere
Forventede deltagere med prøver
Inkluderede deltagere med prøver
Analysis of coagulation in patients with Hereditary Haemorrhagic Telangiectasia (HHT)
Objective: The aim is to investigate if the platelet function in HHT patients with epistaxis
Method: A case-control study with 30 HHT-patients (epistaxis severity score≥4) and 20 healthy controls match by sex and age is planned.. All will complete a questionnaire regarding bleeding. The platelet function will be assessed by; standard hemostasis parameters, flow cytometry, thromboelastogram, Multiplate (plateletaggregation) and Platelet Function Analyzer 200 (realistic hemodynamic environment).
Numerous teleangeictasia increase the risk of bleeding from mucosal surfaces among HHT-patients. The primary hemostasis with the platelet function plays a role in bleeding tendency . The aim is to investigate if the platelet function in HHT patients with epistaxis.
Description of the cohort
30 patients with Hereditary Haemorrhagic Telangiectasia, also known as Morbus Osler. Included via Department of ORL - Head & Neck Surgery.
Data and biological material
Blod samples, questionnaire about bleeding and Epistaxis Severity Score
Collaborating researchers and departments
The Department of Clinical Biochemisty and Pharmacology, Odense University Hospital
associate professor and Ph.D., Pernille Just Vinholt
Department of ORL - Head & Neck Surgery, Odense University Hospital
Professor and Ph.D., Anette Drøhse Kjeldsen
Department of Clinical Immunology, Odense University Hospital