Sarcopenia, Fall and Osteoporosis in Patients with Chronic Kidney Disease
The study wishes to investigate whether there is an increased incidence of
sarcopenia in patients with chronic kidney disease compared to the Danish
background population. A possible association between sarkopenia and fall, as
well as the incidence of osteoporosis in patients with chronic kidney disease will
also be described.
Sarcopenia is a condition diagnosed from different clinical findings such
as low muscle mass, low muscle strength and possibly also poor physical
performance. In the general population, the risk of fall and bone fracture
increases, when sarcopenia is also present.
Sarcopenia is known to occur in patients with chronic kidney disease, but
whether, and if so, how this differs from the incidence in patients without kidney
disease has not previously been described.
The association between sarcopenia, risk of falls and osteoporosis in patients
with kidney disease is until now sparsely described, and because of this, we
want to explore this further.
Description of the cohort
• Age ≥20 years
• Chronic kidney disease stage 4-5nonD (corresponding to an estimated
glomerular filtration rate (eGFR) ≤30 ml/min based on KDIGO definition
and not on dialysis)
Data and biological material
Patients undergo physical examination, deliver blood samples, fill out a questionnaire, undergo a DEXA
scan and different procedures to estimate muscle function and muscle strength.
Collaborating researchers and departments
Department of Endocrinology, Odense University hospital
- Morten Frost Nielsen, associate professor MD PhD
Department of Nephrology, Odense University Hospital
Department of Nephrology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark
- Ditte Hansen, associate professor MD PhD
- Anahita Rashid, MD
Department of Medicine, Geriatric Research Unit, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark
- Charlotte Suetta, professor MD PhD
Department of Nuclear Medicine, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark