OPEN Research Support

Peter Biesenbach
Department of Emergency Medicine, University Hospital of South West Jutland

Projekt styring
Projekt status    Open
Data indsamlingsdatoer
Start 24.10.2022  
Slut 14.12.2022  

Rapid infusion of Ringer's lactate solution at different temperatures and the effects on circulation and perfusion in healthy volunteers - a randomized crossover trial

Short summary

This randomized controlled crossover study investigates the effect of 3000 ml of Ringer's lactate solution at high (37°) and low (15°) temperatures on physiological response in healthy adults. We aim to test whether cold fluids, compared to warm fluids, increase blood pressure more profoundly and provide a more sustained increase of blood pressure.


We hypothesize that the administration of cold fluids results in more persistent improvements of hemodynamic parameters compared to body temperature in healthy volunteers.

Description of the cohort

Healthy volunteers between the age of 18 and 64.

Data and biological material

Blood samples, hemodynamic monitoring, temperature, skin perfusion

Collaborating researchers and departments

Department of Emergency Medicine, Odense University Hospital

  • Mikkel Brabrand