PhD student, MD Nina Vestergaard Simonsen Research Unit for Plastic Surgery, OUH
Projektet i tal
OPEN undersøgelse/kliniske data
Forventet # af deltagere
Inkluderet antal deltagere
Inkluderede deltagere med prøver
Living with Chronic Diabetic Foot Ulcers and Amputation
Diabetic foot ulcers (DFU) are a common complication to diabetes, and can result in amputation and death. To investigate how chronic DFU and amputations affect patients lives, we will perform a prospective cohort study of patients with chronic DFU undergoing amputations. These study will use the condition specific PROM WOUND-Q, the newly developed LIMB-Q and the generic PROM EQ-5D-L5. Patients will be followed 1 year after amputation.
Diabetes patient's life expectancy are increasing, which leads to increased
prevalence of diabetes related disorders such as diabetic foot ulcers (DFU). Up to
34% of diabetic patients will develop a foot ulcer at some point in their lives. DFU
is a major warning sign, as the risk of death and lower extremity amputation (LEA)
rise. LEA related to diabetes is more dangerous than serious illness such as
cancer, as only 50% of diabetics having amputations will be alive after one year.
Due to this severity, numerous initiatives have been taken to detect and prevent
DFU in the primary and secondary sector. Since DFU and LEA have great impact
on the patients' quality of life and function, it is of great importance to collect
patient-reported outcomes (PRO), to enlighten the patient perspective.
Patients with DFU and LEA are a fragile and diverse population, requiring intensive treatment, frequent appointments, broadly interdisciplinary collaboration, and good and effective treatment across sectors. Despite wide agreement of the importance of collecting PRO, in health-care evaluation, quality assessments, treatment evaluation and shared-decision making, PRO are not routinely collected among patients with DFU and LEA.
The overall aim of this project is to enlighten how the lives of patients with
chronic diabetic foot ulcers and amputations
Description of the cohort
Patients with a chronic diabetic foot ulcer, speaking and reading Danish and > 18 years, will be recruited from the department of Vascular surgery at Kolding Hospital, and the wound care center at OUH. Patients will be invited at ambulatory visits or under admission.
Data and biological material
PROMs (WOUND-Q, LIMB-Q, EQ-5D)
Data from the patient journal (blood samples, treatment information, wound characteristics, diagnosis)
Collaborating researchers and departments
Department of Vascular Surgery, Kolding Hospital
Department of Orthopedic surgery, Kolding Hospital