Milk Fat Globule Membrane (MFGM) and Extracellular Vesicles (EV) in preterm and term human milk

Sofie Dahl-Nielsen
Gitte Zachariassen
HC Andersen Children's Hospital, OUH and SDU

Project management

Project status	Open



Data collection dates
Start	16.07.2023
End	31.05.2025

Project in numbers

OPEN survey/clinical data
Expected # of participants	60
Included # of participants	53





Included participants with specimens
Specimens

Milk Fat Globule Membrane (MFGM) and Extracellular Vesicles (EV) in preterm and term human milk

Short summary

Both MFGMs and EVs serve important nutritional and bioactive purpose for the developing infant. Infant term formulas supplemented with polar lipids from MFGM and EVs show well documented health benefits in term infants, including improved neuro- and cognitive development, less incidences of diarrhea, protective immunological and metabolic effects. We hypothesize preterm infants also will benefit from MFGM and EV added to donor human milk or pretem formula.

Rationale

The present study aims to determine the amount of MFGM and EVs in preterm milk with the perspective to assess how much MFGM/EV should be added to improve the nutrition for preterm infants.

Description of the cohort

30 women who delivered a preterm born infant (before GA 35 weeks) 30 women who delivered a term born infant (after GA 36 weeks)

Data and biological material

Human milk samples and • GA at delivery • Birthweight of the infant(s) in gram • Smoking (how many each day) • Delivery method (vaginal/caesarian section) • Pre pregnancy BMI • Child number • Gender • Single or twin/multiple birth

Collaborating researchers and departments

SDU, ARLA Food Ingredients, Aarhus University