PhD-student
Kevin Heebøll Nygaard
Dep. of Orthopedics, Sygehus Sønderjylland
| Project management | ||
| Project status | Open | |
| Data collection dates | ||
| Start | 07.11.2023 | |
| End | 01.04.2025 | |
Perioperative methadone compared to placebo in elderly hip fracture patients - a randomized controlled trial. MetaHip trial 2
Short summary
Hip fractures are associated with severe pain and are sustained by the elderly population. Demand for adequate pain relief combined with a low tolerance for analgesic drugs makes the treatment of elderly hip fracture patients difficult. Perioperative methadone could improve the analgesic treatment of these patients. Our pilot study showed that 0.10 mg/kg was the optimal dose for this patient group. This study further investigates the advantages of methadone.
Rationale
Introduction: Hip fractures are recognized as the most serious consequence of osteoporosis and low-energy trauma because of their complications which include chronic pain, disability, diminished quality of life, and premature death. With the expanding elderly population, the global incidence of hip fractures is expected to rise from 1.66 million in 1990 to 6.26 million by 2050 rendering them an established health problem worldwide. Hip fractures are associated with severe pain and thus require adequate analgesic treatment. However, hip fractures are predominantly sustained by the elderly population who possess a lower tolerance for analgesic drugs. The demand for adequate pain relief combined with a low tolerance for analgesic drugs makes the analgesic treatment of elderly hip fracture patients extremely difficult and calls for further studies on the subject. Aim: To investigate the analgesic effects of a single dose of methadone given during hip fracture surgery.
Description of the cohort
The study setting is a regional hospital in the emergency- and orthopedic departments. The study will consecutively include patients ≥ 60 years presenting with an acute hip fracture on x-rays.
Data and biological material
We use no biological materials. Data consist of clinical observations noted on an observation chart. The chart is filled in by nurses at the orthopedic ward.