OPEN Research Support
head

Consultant
Stavros Chrysidis
Department of Rheumatology, Hospital of Southwest Denmark, Esbjerg


Projekt styring
Projekt status    Sampling ongoing
 
Data indsamlingsdatoer
Start 01.06.2014  
Slut 31.07.2017  
 



EUREKA - Evaluation of ultrasonic role in patients with suspected extracranial and cranial giant cell arteritis

Short summary

The main objective of this project is to explore the diagnostic accuracy of US examination of supraaortic arteries in the GCA diagnosis.


Rationale

Background:

Giant Cell Arteritis (GCA) is the most common systemic vasculitis and the incidence is higher in Scandinavian populations. A positive temporal artery biopsy (TAB) is considered as the diagnostic gold standard; nonetheless, up to 44% of TAB-negative patients are clinically diagnosed to have GCA. Vascular ultrasound (US) can be used as a diagnostic tool in GCA but to date there are not made multicenter studies using standardized machine settings/operator education and high resolution machines.

Main objective: 

To explore the diagnostic accuracy of US examination of supraaortic arteries in the GCA diagnosis.

Methods: 

Patients suspected for GCA will be US evaluated in 3 Danish centers by 5 rheumatologists trained by the same program, using high resolution US machines with equal settings. All patients will undergo a TAB, right after the US examination.

Six months after study inclusion the final diagnosis will be made by a rheumatologist blinded to US data. All US images will be evaluated by an expert blinded to all patient data.


Description of the cohort

This is a multicenter, prospective, non-interventional observational study. Patients suspected to have GCA will be included in 3 Danish Centers with a follow-up visit after 6 months for confirmation of the diagnosis.


Data and biological material

There will be collected, clinical and para-clinical data at baseline and 6 months later. 


Collaborating researchers and departments

Department of Rheumatology, Hospital of Southwest Denmark, Esbjerg

  • Consultant Stavros Chrysidis, MD
Department of Internal Medicine, Diagnostic Centre Region Hospital Silkeborg
  • Consultant Ulrich Fredberg, MD
Center for Rheumatology and Spine Diseases, Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Glostrup
  • Consultant Uffe Møller Døhn, MD, PhD
Diagnostic Centre, Region Hospital Silkeborg
  • Consultant Tove Lorenzen, MD
Copenhagen University Hospital Glostrup, Copenhagen, Denmark
  • Lene Terslev, MD, PhD
Department of Otolaryngology, Southwest hospital, Esbjerg, Denmark
  • Consultant Knud Larsen, MD
Department of Rheumatology, Haugesund Hospital for Rheumatic Diseases, Haugesund, Norway
  • Consultant Andreas P. Diamantopoulos, MD, PhD