PhD-studendt
Sven Karstensen
Department of Regional Health Research
| Project management | ||
| Project status | Open | |
| Data collection dates | ||
| Start | 01.11.2022 | |
| End | 31.10.2025 | |
Adult granulosacelle tumorer - kræftrelaterede mutationer og associerede cancere
Short summary
Adult granulosa cell tumors (aGCT) are rare cancers of the ovary. Women diagnosed with aGCT have an increased risk of developing breast and uterine cancers. We aim to establish a well described aGCT-cohort and perform tumor-DNA sequencing to explore if molecular changes can determine an increased risk of devoloping other primary cancers.
Rationale
Adult granulosa cell tumors (aGCT) are rare cancers of the ovary. Most aGCT are diagnosed at an early stage and have favorable outcome. However, roughly 30% relapse and are difficult to treat. Additionally, women diagnosed with aGCT have an increased risk of developing breast and uterine cancers. Until now the primary source for this association has been reported in selected cohorts or case-series. We aim to establish a comprehensive aGCT-cohort and perform tumor-DNA sequencing to explore if molecular changes can determine an increased risk of devoloping other primary cancers.
Description of the cohort
Women diagnosed with aGCT from 1980-2022.
Data and biological material
Available formaline fixed paraffine embedded aGCT tumor tissue.
Collaborating researchers and departments
Patologisk afdeling, Herlev Hospital