Short summary

To investigate whether the presence of pre-specified viruses in nasopharyngeal aspirates in an unselected cohort of term neonates at birth during the Covid-19 lockdown is associated with neonatal morbidity and increased rate of infections during the first 2 years of life.

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Rationale

The primary objective of this research is to explore the correlation between the presence of a virus in the nasopharyngeal suction samples of neonates at the time of birth and the subsequent occurrence of infections and complications either during or following the birth process. Additionally, we aim to assess the well-being of these children during their initial two years of life.

The nasopharyngeal aspirations are examined, with PCR, for 12 common viruses associated with neonatal infections. Little is known about the prevalence of these viruses, and there is very limited knowledge as to the consequences of having a virus. The limited information about how often perinatal viral infections happen and what they can cause highlights why this study is crucial.

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Description of the cohort

Neonates born in 2020/2021 who have participated in a project regarding COVID-19.

Data and biological material

At birth, nasopharyngeal suction samples were collected. The children whose nasopharyngeal suction tested positive for a virus by PCR, along with a PCR-negative control group, will be accessed in the Electronic Patient Journal (EPJ). Their medical records will be reviewed for infection-related symptoms, including biochemistry, microbiology, antibiotic usage, and diagnostic codes.

Collaborating researchers and departments

Department of Clinical Microbiology, Vejle Hospital

• Stine Yde Nielsen