Pregnancy loss: the possible link to selenium status, polycystic ovary syndrome and uterine malformations

PhD-student
Nicolaj Bruun Brandt
Department of endocrinology

Project management

Project status	Open



Data collection dates
Start	03.12.2023
End	01.12.2026

Project in numbers

OPEN survey/clinical data
Expected # of participants	500
Included # of participants





Included participants with specimens
Specimens

Pregnancy loss: the possible link to selenium status, polycystic ovary syndrome and uterine malformations

Short summary

Pregnancy loss (PL) occurs in one of four pregnancies. Aneuploidy (incorrect chromosome number) constitutes 60% of PLs, and the remaining 40% are euploid (correct chromosome number). Euploid PL is more prevalent in women with recurrent PL, which suggests maternal causes. Nutritional, hormonal, and anatomical factors associate with PL. Selenium (SE) intake may be related directly to PL or indirectly via thyroid status. Furthermore, women with polycystic ovary syndrome (PCOS).

Description of the cohort

Women / couples from the department of gynaecology with missed abortion.

Data and biological material

Blood samples, urine, sperm and fetal tissue

Collaborating researchers and departments

The department of gynaecology, Hvidovre Hospital