PhD-student
Debbie Salling Norring-Agerskov
OPEN Odense Patient data Explorative Network, Odense University Hospital
| Projekt styring | ||
| Projekt status | Closed | |
| Data indsamlingsdatoer | ||
| Start | 01.09.2008 | |
| Slut | 01.08.2019 | |
Biochemical and genetic factors as predictors of mortality in hip fracture patients
Short summary
The aim of this study is to investigate biochemical and genetic factors, which can predict the outcome in patients following a hip fracture. The knowledge obtained can be used to focus and individualize the treatment and thereby help reduce the risk of mortality.
Rationale
Hip fractures constitute a worldwide public health problem among the elderly. Several studies have demonstrated an increased risk of both morbidity and mortality in hip fracture patients. Within 3-12 months after a hip fracture, there is a 20-30% increased risk of mortality. Despite this, the research in this area is limited compared to other major diseases.
It is very important to identify patients at particularly high risk of mortality, since fast track programs, orthogeriatrics and similar programs have been shown to reduce the number of complications and mortality.
A simple combination of biochemical/genetic markers and other known risk factors such as age, sex, ASA score, Charlson Comorbidity Index (CCI) and dementia might be used to select high risk patients for these kinds of intensive care.
The aim of this study is therefore to further investigate biochemical and genetic factors, which can predict the outcome in patients following a hip fracture.
The knowledge obtained can be used to focus and individualize the treatment and thereby help reduce the risk of mortality.
The investigation will be based on the results of blood samples analyzed at Department of Clinical Biochemistry at Bispebjerg University Hospital.
Description of the cohort
Hip fracture patients admitted to Bispebjerg Hospital in the period 2008-2012, aged 60 years and above.
Data and biological material
Since 2008 every hip fracture patient admitted to Bispebjerg Hospital has been registered, resulting in a Hip Fracture Database containing the following variables: ID-number (CPR), hospital department, admission date, code of diagnosis, date of surgery, type of surgery and date of discharge, alcohol, smoking, living situation, type of fracture, memory status, height, weight, ASA-score and New Mobility Score.
We have collected biological materials in form of whole blood, serum and plasma constituting the biobank used in the study. Additionally, we will collect further information about risk factors such as demographics, medication use, socioeconomic factors and prior diseases from Statistics Denmark.
Collaborating researchers and departments
Research Center for Aging and Osteoporosis, Glostrup Hospital and OPEN Odense Patient data Explorative Network, Odense University Hospital
- Professor Niklas Rye Jørgensen, DMSc, PhD
Department of Orthopedic Surgery, Bispebjerg Hospital
- Professor Jes Bruun Lauritzen, DMSc
- Henrik Jørgensen, MD, PhD
- Ole Birger Vesterager Pedersen MD, PhD
- Lise Bathum, MD, PhD
Publications associated with the project