OPEN Research Support

Dorte Glintborg
Deparment of Endocrinology, Odense University Hospital

Projekt styring
Projekt status    Sampling finished
Data indsamlingsdatoer
Start 15.04.2013  
Slut 01.01.2030  

Morbidity and mortality in polycystic ovary syndrome (PCOS)

Short summary

Polycystic ovary syndrome (PCOS) is the most common hormonal disease among women in the fertile age and is seen in 5-8 %. PCOS is characterized by hyper-inflammation and insulin resistance, which along with obesity may be associated with increased morbidity.

The aim of this register study is to investigate the linkage between the PCOS diagnosis, illness and mortality.


Polycystic ovary syndrome (PCOS) is a prevalent endocrine condition, which is most often defined according to the Rotterdam criteria. Importantly, PCOS is a diagnosis of exclusion and the Rotterdam criteria include irregular ovulation, polycystic ovaries, and/or biochemical/clinical hyperandrogenism.

Many different medical conditions have been associated with the diagnosis of PCOS. Patients with PCOS have a higher risk of developing metabolic syndrome and diabetic mellitus type 2. Recommendations for the diagnosis and follow-up of patients with PCOS include screening for the metabolic syndrome and other cardiovascular risk factors with regular intervals. Quality of life is impaired in patients with PCOS and the risk of depression is approximately eight times increased compared to controls. Hyperandrogenemia, insulin resistance and obesity could be associated with decreased fracture risk, but few studies evaluated this hypothesis.

The aim of this register study is to investigate the linkage between the PCOS diagnosis, illness and mortality.

  • Primary outcomes
    • Mortality
    • Cardiometabolic diseases
    • Fractures
  • Secondary outcomes
    • Medicine prescriptions
    • ICD-diagnosis codes
    • Outcomes of birth
    • Socioeconomic data

Description of the cohort

Population 1, PCOS Odense University Hospital: Premenopausal women referred to the outpatient clinic at the Department of Endocrinology and Metabolism Odense University Hospital during 1997-2012 with the diagnoses hirsutism (L680) and/or PCOS (E282).

Population 2, PCOS Denmark: Patients diagnosed with hirsutism or PCOS according to the International Classification of Diseases (ICD) 10 (L680 and E282) in the Danish NPR from 1995 to 2012 over the age of 12 years.

Controls: For each patient in the PCOS Denmark population three controls are randomly drawn from the NPR. The controls are born in the same year as PCOS cases and have to be alive on the index date of their respective PCOS case.

Data and biological material

Integration with The National Patient Register, The Register of Causes of Death, The Medical Birth Registry, The Pharmaceutical database and data from Statistics Denmark for identification and co-variants (co-morbidity, use of pharmaceuticals and socio-economic factors). Data is processed through OPENs authorization for Statistics Denmark which provides remote access to data.

Collaborating researchers and departments

Department of Endocrinology, Odense University Hospital

  • Consultant Endocrinologist Dorte Gintborg, PhD
  • Clinical Professor Marianne Andersen, MD

OPEN Odense Patient data Explorative Network, Odense University Hospital

  • Associate professor Katrine Hass Rubin, PT, MHS, PhD

OPEN Odense Patient data Explorative Network, Odense University Hospital Osteoporosis Clinic, Holbæk Hospital

  • Clinical Professor and Consultant Endocrinologist Bo Abrahamsen, PhD

Department of Clinical Biochemistry and Pharmacology, Odense University Hospital

  • Clinical Associate Professor Mads Nybo, MD