Identification of pseudoresistant patients among patients with uncontrolled epilepsy

Consultant
Christoph Patrick Beier
Department of Neurology, Odense University Hospital

Project management

Project status	Sampling ongoing



Data collection dates
Start	01.04.2017
End	30.04.2020

Project in numbers

OPEN survey/clinical data
Expected # of participants	40
Included # of participants	45





Included participants with specimens
Specimens

Identification of pseudoresistant patients among patients with uncontrolled epilepsy - a prospective intervention

Short summary

This study aims at analyzing the impact of intensive treatment by specialist nureses on the outcome, quality of life and seizure control. Target group are patients with uncontrolled epilepsy that are refractory according to ILAE. Primary outcome is the proportion of patients that are identified as pseudorefractory, time-to epilepsy surgery is one of the secondary endpoints.

Rationale

The ILAE definition of refractory epilepsy is challenged by the fact, that a substantial proportion of patients fails to become seizure free due to imcomplicance to medication, general rules of conduct, or due to incorrect diagnosis or epilepsy classification ("pseudorefractory patients"). These patients shall be identified using intensive treatment by epilepsy nurses with focus on pseudorefractory patients, while refarctory patients shall be rapidly referred to epilepsy surgery.

Description of the cohort

Patients with uncontrolled epilepsy.