OPEN Research Support
head

Physician
Diana Lydia Dyrberg
Department of Plastic Surgery, Odense University Hospital


Projekt styring
Projekt status    Sampling ongoing
 
Data indsamlingsdatoer
Start 01.05.2017  
Slut 30.04.2020  
 



Direct to implant extracellular matrix hammock based pre- or retropectoral breast reconstruction

Short summary

Different techniques for immediate breast reconstruction following mastectomy have been introduced. Prepectoral/subglandular implant placement using a full extracellular hammock has shown to entail benefits regarding a lesser degree of involuntary deformation of the implant when activating the m. pectoralis major (breast animation deformity) compared to the standard method of retropectoral/submuscular placement of the implant.

Women eligible for immediate breast reconstruction will be invited to participate in this randomized controlled trial where subglandular and submuscular placement of the implant will be compared. Between groups we will assess the degree of breast animation deformity; quality of life; postoperative pain; postoperative complications; shoulder and arm function; surgical corrections; length of stay; capsular contraction; aesthetic outcome and temperature evaluation.  


Description of the cohort

Women over 18 years referred to the Department of plastic surgery, Odense University Hospital, Lillebaelt Hospital, Vejle, Denmark or Telemark Hospital, Skien, Norway between April 2017 and July 2018, who are found eligible for immediate breast reconstruction using the retropectoral implant placement are invited to participate in the study.


Data and biological material

Before surgery all relevant data will be collected in the outpatient clinic. This includes an interview, photo and video recordings of the breast with and without movement of the pectoralis major muscle, clinical examination including shoulder and arm function, photography and the completion of a Breast-Q questionnaire.

Patients are closely monitored after surgery as all relevant data are collected, and the different end-points are evaluated at 3 and 12 month in the outpatient clinic after they are discharged from the hospital.


Collaborating researchers and departments

Department of Plastic Surgery, Odense University Hospital

  • PhD Student Diana Lydia Dyrberg, MD
  • Consultant Jørn Bo Thomsen, PhD
  • Camilla Bille, MD, PhD
  • Professor and consultant Jens Ahm Sørensen PhD