OPEN Research Support
head

Physician
Martin Lindberg-Larsen
Department of Orthopedic Surgery, Odense University Hospital


Projekt styring
Projekt status    Sampling ongoing
 
Data indsamlingsdatoer
Start 01.11.2017  
Slut 31.10.2022  
 



One-stage Versus Two-stage Revision of the Infected Knee Arthroplasty

Short summary

This randomized controlled study investigates functional outcome and safety after one-stage versus two-stage revision of the infected knee arthroplasty.

Half of participants are treated with a one-stage surgical procedure, while the other half is treated with a two-stage procedure.

The investigators hypothesize that the functional outcome and quality of life of the participants is superior after one-stage surgery compared to two-stage surgery.



Rationale

A two-stage approach is the standard surgical procedure in the treatment of the chronically infected knee arthroplasty, but promising results have been reported after a one-stage approach from single-centre studies.

The potential benefits for the patients treated with a one-stage approach are many as they only have to go through surgery and rehabilitation once with shorter total length of hospital stay. However, no randomized controlled trials comparing outcome after the procedures have been performed so far.

The aim of this study is to investigate functional outcome and safety after one-stage versus two-stage revision of the infected knee arthroplasty.



Description of the cohort

Adult patients:

  • Clinical signs of periprosthetic knee infection
  • > 6 weeks from previous knee arthoplasty procedure (primary or total revision procedure)
  • Speak and understand Danish and have given informed consent



Data and biological material

Questionaires (Oxford Knee Score, 2.EQ-5D-5L)

Clinical data (re-revisions, readmissions, mortality, length of hospital stay)


Collaborating researchers and departments

Department of Orthopedic Surgery, Odense Universitets Hospital

  • Martin Lindberg-Larsen, MD, PhD   

Department of Orthopedic Surgery, Aalborg University Hospital

  • Andreas Kappel, MD           

Department of Orthopedic Surgery, Aarhus University Hospital

  • Claus Fink, MD           

Department of Orthopedic Surgery, Bispebjerg Hospital

  • Jens Bagger, MD           

Department of Orthopedic Surgery, Gentofte Hospital

  • Anders Odgaard, MD, PhD           

Department of Orthopedic Surgery, Horsens Hospital

  • Jeppe Lange, MD, PhD           

Department of Orthopedic Surgery, Køge Hospital

  • Jesper Fabrin, MD           

Department of Orthopedic Surgery, Næstved Hospital

  • Henrik Schrøder, MD           

Department of Orthopedic Surgery, Silkeborg Hospital

  • Carsten Holm, MD           

Department of Orthopedic Surgery, Vejle Hospital

  • Thomas Bruno Lind-Hansen, MD, PhD