Short summary

The purpose of the project is to study the epidemiology of intracerebral haemorrhage (ICH) with focus on the association between this disorder and use of drugs. 

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Rationale

The main aims of this project are to determine:

• validity of ICH diagnosis in Danish registries
• association between use of various drugs, eg, antithrombotics, and risk of ICH
• association between use of various drugs and prognosis after ICH

As part of this project, the above aims will be extended to other forms of intracranial haemorrhage, ie, subdural haematoma and subarachnoid haemorrhage. 

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Description of the cohort

The project comprises nationwide and regional studies based on several observational designs, including case-control, and cohort studies. Danish registries will be used to identify patients, and their corresponding controls or comparison cohorts. Information from registries will be used to classify exposure to drugs and comorbidity of individuals included in the studies. 

Data and biological material

Data will be retrieved from several registries, including the Danish National Patient Registry, the Danish Stroke Registry, national and regional prescription registries, and the Danish Civil Registration System. The nationwide studies will be further supplemented with information from registries available at Statistics Denmark, where the nationwide data will be stored. Regional data will be supplemented with information retrieved from medical records, and imaging studies and will be stored at Department of Neurology, Odense University Hospital.

Collaborating researchers and departments

Department of Neurosurgery, Odense University Hospital

• Professor Frantz R. Poulsen, PhD, MD

Odense Patient Data Explorative Network - OPEN

• Associate professor Sören Möller, Master of Science in Mathematics, PhD

Department of Pharmacology and Clinical Pharmacy, University of Southern Denmark

• Professor Jesper Hallas, DMsc, MD
• Associate Professor Anton Pottegård, PhD

Spanish Centre of Pharmacoepidemiology (CEIFE), Madrid, Spain

• Director, Luis Alberto García Rodríguez, MD

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom

• Professor Rustam Al-Shahi Salman, PhD, MD

Publications associated with the project

Jensen MM, Hald SM, Kristensen LMB, Boe NJ, Harbo FSG, Gaist D. Validity of Simple Algorithms to Identify Recurrence of Intracerebral Hemorrhage in Two Danish Nationwide Registries. Clin Epidemiol. 2021 Oct 9;13:949-958. doi: 10.2147/CLEP.S333624. PMID: 34675683; PMCID: PMC8517414.

Hald SM, Möller S, García Rodríguez LA, Al-Shahi Salman R, Sharma M, Christensen H, Hellfritzsch M, Pottegård A, Hallas J, Gaist D. Trends in Incidence of Intracerebral Hemorrhage and Association With Antithrombotic Drug Use in Denmark, 2005-2018. JAMA Netw Open. 2021 May 3;4(5):e218380. doi: 10.1001/jamanetworkopen.2021.8380. PMID: 33950207; PMCID: PMC8100864.

Hald SM, Kring Sloth C, Agger M, Schelde-Olesen MT, Højholt M, Hasle M, Bogetofte H, Olesrud I, Binzer S, Madsen C, Krone W, García Rodríguez LA, Al-Shahi Salman R, Hallas J, Gaist D. The Validity of Intracerebral Hemorrhage Diagnoses in the Danish Patient Registry and the Danish Stroke Registry. Clin Epidemiol. 2020 Dec 1;12:1313-1325. doi: 10.2147/CLEP.S267583. PMID: 33293870; PMCID: PMC7719118.

Hald SM, Kring Sloth C, Hey SM, Madsen C, Nguyen N, García Rodríguez LA, Al-Shahi Salman R, Möller S, Poulsen FR, Pottegård A, Gaist D. Intracerebral hemorrhage: positive predictive value of diagnosis codes in two nationwide Danish registries. Clin Epidemiol. 2018 Aug 7;10:941-948. doi: 10.2147/CLEP.S167576. PMID: 30123006; PMCID: PMC6086098.