Professor Ellen Aagaard Nøhr Department of Gynaecology and Obstetrics, Odense University Hospital
Projektet i tal
OPEN undersøgelse/kliniske data
Forventet # af deltagere
Inkluderet antal deltagere
Inkluderede deltagere med prøver
The influence of pregnancy, birth and childhood on short- and long-term health. A follow-up study of mothers and children in the cohort 'Healthy Habits for Two'
This follow up study builds on the cohort 'Healthy Habits for Two' where 12,000 pregnant women and their children were recruited in late pregnancy during the years 1984-87. Questionnaire follow ups of the children and comprehensive register follow ups of both mothers and children allow studies of how exposures in early life affect health in a lifecourse perspective.
The early origin of disease hypothesis, that many aspects of both health and disease may have its origin in fetal life and early childhood, was the main motivator for establishing this follow-up study, which builds on the cohort 'Healthy Habits for Two' where 12,000 pregnant women and their children were recruited in late pregnancy during the years 1984-87 at Aalborg Hospital and Odense Hospital. Two questionnaire followups focusing on the children were carried out in adolescence and data from a comprehensive register followup of both mothers and children were retrieved in 2018.These data allows studies of how exposures in early life relate to later health in the children, from birth until adulthood. Also, rich data on exposures, lifestyle and health of the mothers allow important studies of maternal health in a lifecourse perspective.
Description of the cohort
12,000 women recruited in late pregnancy - on average 60 years of age at end of follow-up. 12,000 children followed from birth and until on average 30 years of age. Half of the women/children habitated in Aalborg municipality at time of birth, the other half in Odense municipality.
Data and biological material
Questionnaire date in late pregnancy on demographics and life style habits; birth outcomes and medical information from medical records at birth; a questionnnaire focusing on the children at 14 years of age, filled out by the mothers; a questionnaire at 18 years of age, filled out by the children; Follow-up data on the mothers from the period 1978 - 2018 in national health registers, Follow up data on the children from birth until 2018 in national health registers. No biological material.
Collaborating researchers and departments
Department of Gynaecology and Obstetrics, Odense University Hospital
Professor Ellen Aagaard Nøhr
Associate Professor Chunsen Wu
Department of Clinical Epidemiology, Aarhus University Hospital