OPEN Research Support

Professor and consultant
David Gaist
Department of Neurology, Odense University Hospital

Projekt styring
Projekt status    Sampling ongoing
Data indsamlingsdatoer
Start 01.01.2011  
Slut 31.12.2023  

Women with Migraine with Aura Neuroimaging (WOMAN) study

Short summary

We collected MRI brain scan and interview data from women with a diagnosis of migraine with aura (cases) and from migraine-free controls. All participants were identified through the population-based Danish Twin Registry. A single 3-Tesla MRI scanner was used for brain imaging. The collected data allow comparisons of brain imaging results of cases with controls (individual-based analyses). For a subset of data, comparisons of cases with their co-twins are also available (within-pair analyses). 


Description of the cohort

Women aged 30 to 60 years (n=345).

Cases: women with migraine with aura according to IHS criteria (lifetime diagnosis) (n=172)

Controls: women with no history of migraine of any type, or frequent tension-type headache (n=139)

Co-twins: women with no history of migraine with aura whose twin sister suffered from this headache form; the co-twins could suffer from migraine without aura (n=34). 

Data and biological material

Brain MRI imaging results, questionnaire and interview data, blood test results (lipid levels, HgA1C). 

Questionnaire and interview data are also available for a larger cohort of women from which we identified participants for the brain imaging study.

Collaborating researchers and departments

Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup

  • Professor Messoud Ashina

Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre

  • Professor Hartwig Siebner

The Danish Twin Registry

  • Professor Kirsten Ohm Kyvik 


Publications associated with the project

Brain 2016;139:2015-2023

Brain 2018; 141: 776-785