Short summary

We aim to investigate if specific genetic mutations causing functional and morphological changes of the heart muscle, affects certain heart specific proteins. The hypothesis is that genetic mutations cause changes in specific proteins and that these changes are measurable as biomarkers in the blood.

Description of the cohort

The cohort consists of patients with heart muscle disease (cardiomyopathies). Patients are recruited from Odense University Hospital, Aarhus University Hospital, Aalborg University Hospital and Vejle Hospital.

Data and biological material

Clinical data (date of diagnosis, symptoms, ECG, echocardiography etc.) from each patient is collected in a database, in addition to blood samples stored in a biobank.

Collaborating researchers and departments

The Department of Cardiology, Odense University Hospital

• Professor Jens Mogensen, MD, DMSc
• , PhD-student Thomas Morris Hey, MD

The Department of Cardiology, Aarhus University Hospital

• Professor Henning Mølgaard, MD, DMSc
• Hans Eiskjær, MD, DMSc

The Department of Cardiology, Aalborg University Hospital

• Trine Madsen, MD, PhD

The Department of Cardiology, Vejle Hospital

• Ulrik Eriksen, MD, PhD
• Thomas Fischer, MD, PhD

Publications associated with the project

Pathogenic RBM20-Variants Are Associated With a Severe Disease Expression in Male Patients With Dilated Cardiomyopathy. Hey TM1, Rasmussen TB, Madsen T, Aagaard MM, Harbo M, Mølgaard H, Møller JE, Eiskjær H, Mogensen J. Circ Heart Fail. 2019 Mar;12(3):e005700. doi: 10.1161/CIRCHEARTFAILURE.118.005700